Expanding the Genetic Code of Lactococcus lactis and Escherichia coli to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics

The incorporation of non-canonical amino acids (ncAAs) into ribosomally synthesized and post-translationally modified peptides, e.g., nisin from the Gram-positive bacterium Lactococcus lactis, bears great potential to expand the chemical space of various antimicrobials. The ncAA N(ε)-Boc-L-lysine (B...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Bartholomae, Maike, Baumann, Tobias, Nickling, Jessica H., Peterhoff, David, Wagner, Ralf, Budisa, Nediljko, Kuipers, Oscar P.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897534/
https://ncbi.nlm.nih.gov/pubmed/29681891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.00657
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