Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome

Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT function may contribute to vascular dysfunction associated with i...

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Veröffentlicht in:Front Physiol
Hauptverfasser: da Costa, Rafael M., da Silva, Josiane F., Alves, Juliano V., Dias, Thiago B., Rassi, Diane M., Garcia, Luis V., Lobato, Núbia de Souza, Tostes, Rita C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897513/
https://ncbi.nlm.nih.gov/pubmed/29681862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00341
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