Metastatic prostate cancer-associated P62 inhibits autophagy flux and promotes epithelial to mesenchymal transition by sustaining the level of HDAC6

P62 (also named sequestosome-1, SQSTM1) is involved in autophagy regulation through multiple pathways. It interacts with autophagosomes-associated LC3-II and ubiquitinated protein aggregates to engulf the aggregates in autophagosomes, interacts with HDAC6 to inhibit its deacetylase activity to maint...

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Detalhes bibliográficos
Publicado no:Prostate
Main Authors: Jiang, Xianhan, Huang, Yiqiao, Liang, Xue, Jiang, Funeng, He, Yongzhong, Li, Tian, Xu, Guibin, Zhao, Haibo, Yang, Weiqing, Jiang, Ganggang, Su, Zhengming, Jiang, Lingke, Liu, Leyuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897115/
https://ncbi.nlm.nih.gov/pubmed/29383752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23487
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