Successful pharmaceutical-grade streptozotocin (STZ)-induced hyperglycemia in a conscious tethered baboon (Papio hamadryas) model

BACKGROUND: Non-human primate (NHP) diabetic models using chemical ablation of β-cells with STZ have been achieved by several research groups. Chemotherapeutic STZ could lead to serious adverse events including nephrotoxicity, hepatotoxicity, and mortality. METHODS: We implemented a comprehensive th...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Med Primatol
Egile Nagusiak: Frost, Patrice A., Chen, Shuyuan, Mezzles, Marguerite J., Voruganti, V Saroja, Nava-Gonzalez, Edna J, Arriaga-Cazares, Hector E, Freed, Katy A., Comuzzie, Anthony G., DeFronzo, Ralph A, Jack W, Kent, Grayburn, Paul A., Bastarrachea, Raul A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897100/
https://ncbi.nlm.nih.gov/pubmed/26122701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jmp.12182
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