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Automated Synthesis of PET Radiotracers by Copper-mediated (18)F-Fluorination of Organoborons: Importance of the Order of Addition and Competing Protodeborylation
In this paper we describe the use of Cu-mediated [(18)F]fluorodeboronation for the automated production of PET radiotracers suitable for clinical use. Two recurrent issues with the method, low radiochemical conversion (RCC) on automation and protoarene byproduct purification issues, have been succes...
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| Publicado no: | J Labelled Comp Radiopharm |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5896751/ https://ncbi.nlm.nih.gov/pubmed/29143408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3583 |
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