Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment

Aging is linked to functional deterioration and hematological diseases. The hematopoietic system is maintained by hematopoietic stem cells (HSCs), and dysfunction within the HSC compartment is thought to be a key mechanism underlying age-related hematopoietic perturbations. Using single-cell transpl...

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Udgivet i:Cell Stem Cell
Main Authors: Yamamoto, Ryo, Wilkinson, Adam C., Ooehara, Jun, Lan, Xun, Lai, Chen-Yi, Nakauchi, Yusuke, Pritchard, Jonathan K., Nakauchi, Hiromitsu
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896201/
https://ncbi.nlm.nih.gov/pubmed/29625072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.03.013
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