Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment

BACKGROUND: The APOBEC gene family of cytidine deaminases plays important roles in DNA repair and mRNA editing. In many cancers, APOBEC3B increases the mutation load, generating clusters of closely spaced, single-strand-specific DNA substitutions with a characteristic hypermutation signature. Some s...

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Vydáno v:Hum Genomics
Hlavní autoři: Vural, Suleyman, Simon, Richard, Krushkal, Julia
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Primary Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896091/
https://ncbi.nlm.nih.gov/pubmed/29642934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40246-018-0150-x
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