Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy

Injuries to flexor tendons can be complicated by fibrotic adhesions, which severely impair the function of the hand. Adhesions have been associated with TGF-β1, which causes upregulation of PAI-1, a master suppressor of protease activity, including matrix metalloproteinases (MMP). In the present stu...

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Publicat a:Sci Rep
Autors principals: Freeberg, Margaret A. T., Farhat, Youssef M., Easa, Anas, Kallenbach, Jacob G., Malcolm, Dominic W., Buckley, Mark R., Benoit, Danielle S. W., Awad, Hani A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895578/
https://ncbi.nlm.nih.gov/pubmed/29643421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24144-1
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