Sodium bicarbonate cotransporter NBCe2 gene variants increase sodium and bicarbonate transport in human renal proximal tubule cells

RATIONALE: Salt sensitivity of blood pressure affects >30% of the hypertensive and >15% of the normotensive population. Variants of the electrogenic sodium bicarbonate cotransporter NBCe2 gene, SLC4A5, are associated with increased blood pressure in several ethnic groups. SLC4A5 variants are a...

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Publicado en:PLoS One
Main Authors: Gildea, John J., Xu, Peng, Kemp, Brandon A., Carlson, Julia M., Tran, Hanh T., Bigler Wang, Dora, Langouët-Astrié, Christophe J., McGrath, Helen E., Carey, Robert M., Jose, Pedro A., Felder, Robin A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895442/
https://ncbi.nlm.nih.gov/pubmed/29642240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189464
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