Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067

Tenofovir (TFV), a nucleotide reverse transcriptase inhibitor, requires two phosphorylation steps to form a competitive inhibitor of HIV reverse transcriptase. Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, musc...

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Udgivet i:PLoS One
Main Authors: Figueroa, Dominique B., Tillotson, Joseph, Li, Maoji, Piwowar-Manning, Estelle, Hendrix, Craig W., Holtz, Timothy H., Bokoch, Kevin, Bekker, Linda-Gail, van Griensven, Frits, Mannheimer, Sharon, Hughes, James P., Grant, Robert M., Bumpus, Namandjé N.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895070/
https://ncbi.nlm.nih.gov/pubmed/29641561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195764
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