Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation

Despite anti-TNF therapy advancements for inflammatory diseases such as rheumatoid arthritis, the burden of diseases remains high. An 11-mer TNF peptide, TNF(70–80), is known to stimulate selective functional responses compared to the parent TNF molecule. Here, we show that TNF(70–80) binds to the T...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Mukaro, Violet R., Quach, Alex, Gahan, Michelle E., Boog, Bernadette, Huang, Zhi H., Gao, Xiuhui, Haddad, Carol, Mahalingam, Suresh, Hii, Charles S., Ferrante, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893557/
https://ncbi.nlm.nih.gov/pubmed/29636466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03640-y
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