Mechanistic insights into allosteric regulation of the A(2A) adenosine G protein-coupled receptor by physiological cations

Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their mechanisms are poorly understood. Here, (19)F NMR is used to delineate the effects of cations on functional states of the adenosine A(2A) GPCR. While Na(+) reinforces an inactive ensemble and a partial-agonist s...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ye, Libin, Neale, Chris, Sljoka, Adnan, Lyda, Brent, Pichugin, Dmitry, Tsuchimura, Nobuyuki, Larda, Sacha T., Pomès, Régis, García, Angel E., Ernst, Oliver P., Sunahara, Roger K., Prosser, R. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893540/
https://ncbi.nlm.nih.gov/pubmed/29636462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03314-9
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