Epitope Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis

HLA-DRB1 is the major genetic risk factor for visceral leishmaniasis (VL). We used SNP2HLA to impute HLA DRB1 alleles and SNPTEST to carry out association analyses in 889 human cases and 977 controls from India. NetMHCIIpan2.1 was used to map epitopes and binding affinities across 49 Leishmania vacc...

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Vydáno v:J Immunol
Hlavní autoři: Singh, Toolika, Fakiola, Michaela, Oommen, Joyce, Singh, Akhil Pratap, Singh, Abhishek Kr., Smith, Noel, Chakravarty, Jaya, Sundar, Shyam, Blackwell, Jenefer M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893436/
https://ncbi.nlm.nih.gov/pubmed/29507109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701764
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