Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL

Clostridium perfringens toxin TpeL belongs to the family of large clostridial glycosylating toxins. The toxin causes N-acetylglucosaminylation of Ras proteins at threonine35 thereby inactivating the small GTPases. Here, we show that all main types of oncogenic Ras proteins (H-Ras, K-Ras and N-Ras) a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Schorch, Björn, Heni, Hannah, Zahaf, Nour-Imene, Brummer, Tilman, Mione, Marina, Schmidt, Gudula, Papatheodorou, Panagiotis, Aktories, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893256/
https://ncbi.nlm.nih.gov/pubmed/29662661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24740
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