Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1

Myotonic dystrophy type 1 (DM1) is a progressive neuromuscular disease caused by expanded CUG repeats, which misregulate RNA metabolism through several RNA-binding proteins, including CUG-binding protein/CUGBP1 elav-like factor 1 (CUGBP1/CELF1) and muscleblind 1 protein. Mutant CUG repeats elevate C...

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Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Wei, Christina, Stock, Lauren, Valanejad, Leila, Zalewski, Zachary A., Karns, Rebekah, Puymirat, Jack, Nelson, David, Witte, David, Woodgett, Jim, Timchenko, Nikolai A., Timchenko, Lubov
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893173/
https://ncbi.nlm.nih.gov/pubmed/29203592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700700R
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