The (95)RGD(97) sequence on the Aα chain of fibrinogen is essential for binding to its erythrocyte receptor

BACKGROUND: Erythrocyte aggregation, a cardiovascular risk factor, is increased by high plasma fibrinogen levels. Here, the effect of different fibrinogen mutations on binding to its human erythrocyte receptor was assessed in order to identify the interaction sites. METHODS: Three fibrinogen variant...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Carvalho, Filomena A, Guedes, Ana Filipa, Duval, Cedric, Macrae, Fraser L, Swithenbank, Luke, Farrell, David H, Ariëns, Robert AS, Santos, Nuno C
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892956/
https://ncbi.nlm.nih.gov/pubmed/29662311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S154523
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