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Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload

Tissue transglutaminase (tTG) is a multifunctional protein with a wide range of enzymatic and non-enzymatic functions. We have recently demonstrated that tTG expression is upregulated in the pressure-overloaded myocardium and exerts fibrogenic actions promoting diastolic dysfunction, while preventin...

詳細記述

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書誌詳細
出版年:J Mol Cell Cardiol
主要な著者: Shinde, Arti V, Su, Ya, Palanski, Brad A, Fujikura, Kana, Garcia, Mario J, Frangogiannis, Nikolaos G
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892840/
https://ncbi.nlm.nih.gov/pubmed/29481819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.02.016
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