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Metabolite profiling reveals the glutathione biosynthetic pathway as a therapeutic target in triple negative breast cancer

Cancer cells can exhibit altered dependency on specific metabolic pathways and targeting these dependencies is a promising therapeutic strategy. Triple negative breast cancer (TNBC) is an aggressive and genomically heterogeneous subset of breast cancer that is resistant to existing targeted therapie...

詳細記述

保存先:
書誌詳細
出版年:Mol Cancer Ther
主要な著者: Beatty, Alexander, Fink, Lauren S., Singh, Tanu, Strigun, Alexander, Peter, Erik, Ferrer, Christina M., Nicolas, Emmanuelle, Cai, Kathy Q., Moran, Timothy P., Reginato, Mauricio J., Rennefahrt, Ulrike, Peterson, Jeffrey R.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892195/
https://ncbi.nlm.nih.gov/pubmed/29021292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0407
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