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Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: chemistry and preliminary evaluation

In a previous study, we evaluated a HER2-specific single domain antibody fragment (sdAb) 2Rs15d labeled with (18)F via conjugation of a residualizing prosthetic agent that was synthesized by copper-catalyzed azide-alkyne cycloaddition (CuAAC). In order to potentially increase overall efficiency and...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Zhou, Zhengyuan, Chitneni, Satish K, Devoogdt, Nick, Zalutsky, Michael R., Vaidyanathan, Ganesan
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891353/
https://ncbi.nlm.nih.gov/pubmed/29534937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.02.040
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