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Understanding intratumor heterogeneity by combining genome analysis and mathematical modeling

Cancer is composed of multiple cell populations with different genomes. This phenomenon called intratumor heterogeneity (ITH) is supposed to be a fundamental cause of therapeutic failure. Therefore, its principle‐level understanding is a clinically important issue. To achieve this goal, an interdisc...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Sci
Hauptverfasser: Niida, Atsushi, Nagayama, Satoshi, Miyano, Satoru, Mimori, Koshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891172/
https://ncbi.nlm.nih.gov/pubmed/29352488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13510
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