Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies

Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we report that current influenza vaccines poorly display key NA epitopes and rarely induce NA-reactive B cells. Conversely, influenza virus infecti...

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Pubblicato in:Cell
Autori principali: Chen, Yaoqing, Wohlbold, Teddy John, Zheng, Nai-Ying, Huang, Min, Huang, Yunping, Neu, Karlynn E., Lee, Jiwon, Wan, Hongquan, Rojas, Karla Thatcher, Kirkpatrick, Ericka, Henry, Carole, Palm, Anna-Karin E., Stamper, Christopher T., Lan, Linda Yu-Ling, Topham, David J., Treanor, John, Wrammert, Jens, Ahmed, Rafi, Eichelberger, Maryna C., Georgiou, George, Krammer, Florian, Wilson, Patrick C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890936/
https://ncbi.nlm.nih.gov/pubmed/29625056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.030
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