Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies

Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we report that current influenza vaccines poorly display key NA epitopes and rarely induce NA-reactive B cells. Conversely, influenza virus infecti...

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Publicado no:Cell
Main Authors: Chen, Yaoqing, Wohlbold, Teddy John, Zheng, Nai-Ying, Huang, Min, Huang, Yunping, Neu, Karlynn E., Lee, Jiwon, Wan, Hongquan, Rojas, Karla Thatcher, Kirkpatrick, Ericka, Henry, Carole, Palm, Anna-Karin E., Stamper, Christopher T., Lan, Linda Yu-Ling, Topham, David J., Treanor, John, Wrammert, Jens, Ahmed, Rafi, Eichelberger, Maryna C., Georgiou, George, Krammer, Florian, Wilson, Patrick C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890936/
https://ncbi.nlm.nih.gov/pubmed/29625056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.030
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