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Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality

Specific variants of endoplasmic reticulum-associated aminopeptidase 1 (ERAP1) identified by genome-wide association study modify the risk for developing ankylosing spondylitis. We previously confirmed that disease-associated ERAP1 variants have altered enzymatic abilities that can impact upon the p...

詳細記述

保存先:
書誌詳細
出版年:Int Immunol
主要な著者: Rastall, David P W, Alyaquob, Fadel S, O’Connell, Patrick, Pepelyayeva, Yuliya, Peters, Douglas, Godbehere-Roosa, Sarah, Pereira-Hicks, Cristiane, Aldhamen, Yasser A, Amalfitano, Andrea
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890900/
https://ncbi.nlm.nih.gov/pubmed/28814066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxx035
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