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Mouse Models of β-cell K(ATP) Channel Dysfunction
ATP-sensitive K(+) (K(ATP)) channels in pancreatic β-cells couple glucose metabolism to insulin secretion. Reduced K(ATP) channel activity produces excessive insulin release and hyperinsulinism whereas increased K(ATP) channel activity leads to lower insulin secretion and diabetes. Paradoxically, mi...
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| izdano v: | Drug Discov Today Dis Models |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5890883/ https://ncbi.nlm.nih.gov/pubmed/29643927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddmod.2013.02.001 |
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