Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

There is significant need to develop physiologically relevant models for investigating human astrocytes in health and disease. Here, we present an approach for generating astrocyte lineage cells in a three-dimensional (3D) cytoarchitecture using human cerebral cortical spheroids (hCS) derived from p...

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發表在:Neuron
Main Authors: Sloan, Steven A., Darmanis, Spyros, Huber, Nina, Khan, Themasap, Birey, Fikri, Caneda, Christine, Reimer, Richard, Quake, Stephen R., Barres, Ben A., Pașca, Sergiu P.
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890820/
https://ncbi.nlm.nih.gov/pubmed/28817799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.07.035
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