Improved power for TB Phase IIa trials using a model-based pharmacokinetic–pharmacodynamic approach compared with commonly used analysis methods

Background: The demand for new anti-TB drugs is high, but development programmes are long and costly. Consequently there is a need for new strategies capable of accelerating this process. Objectives: To explore the power to find statistically significant drug effects using a model-based pharmacokine...

Full description

Saved in:
Bibliographic Details
Published in:J Antimicrob Chemother
Main Authors: Svensson, Robin J., Gillespie, Stephen H., Simonsson, Ulrika S. H.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890728/
https://ncbi.nlm.nih.gov/pubmed/28520930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx129
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items