Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo

Objectives: The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene. Methods: We have...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Sully, Erin K., Geller, Bruce L., Li, Lixin, Moody, Christina M., Bailey, Stacey M., Moore, Amy L., Wong, Michael, Nordmann, Patrice, Daly, Seth M., Sturge, Carolyn R., Greenberg, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890718/
https://ncbi.nlm.nih.gov/pubmed/27999041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw476
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