Physiologically based pharmacokinetic modelling prediction of the effects of dose adjustment in drug–drug interactions between levonorgestrel contraceptive implants and efavirenz-based ART

BACKGROUND: HIV-positive women receiving efavirenz-based ART and levonorgestrel contraceptive implants are at risk of low levonorgestrel exposure and unintended pregnancy. OBJECTIVES: To investigate clinically applicable dose-adjustment strategies to overcome the known drug–drug interaction (DDI) be...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Roberts, Owain, Rajoli, Rajith K R, Back, David J, Owen, Andrew, Darin, Kristin M, Fletcher, Courtney V, Lamorde, Mohammed, Scarsi, Kimberly K, Siccardi, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890694/
https://ncbi.nlm.nih.gov/pubmed/29365101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx515
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge