Physiologically based pharmacokinetic modelling prediction of the effects of dose adjustment in drug–drug interactions between levonorgestrel contraceptive implants and efavirenz-based ART

BACKGROUND: HIV-positive women receiving efavirenz-based ART and levonorgestrel contraceptive implants are at risk of low levonorgestrel exposure and unintended pregnancy. OBJECTIVES: To investigate clinically applicable dose-adjustment strategies to overcome the known drug–drug interaction (DDI) be...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Roberts, Owain, Rajoli, Rajith K R, Back, David J, Owen, Andrew, Darin, Kristin M, Fletcher, Courtney V, Lamorde, Mohammed, Scarsi, Kimberly K, Siccardi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890694/
https://ncbi.nlm.nih.gov/pubmed/29365101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx515
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