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Unravelling the inhibitory activity of Chlamydomonas reinhardtii sulfated polysaccharides against α-Synuclein fibrillation

α-Synuclein (α-Syn) is an intrinsically disordered presynaptic protein, whose aggregation is critically involved in Parkinson’s disease (PD). Many of the currently available drugs for the treatment of PD are not sufficiently effective in preventing progress of the disease and have multiple side-effe...

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Vydáno v:Sci Rep
Hlavní autoři: Choudhary, Sinjan, Save, Shreyada N., Vavilala, Sirisha L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890252/
https://ncbi.nlm.nih.gov/pubmed/29632314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24079-7
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