Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses

Tuberculosis remains a major global health problem and efforts to develop a more effective vaccine have been unsuccessful so far. Targeting antigens (Ags) to dendritic cells (DCs) in vivo has emerged as a new promising vaccine strategy. In this approach, Ags are delivered directly to DCs via antibod...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Velasquez, Lis Noelia, Stüve, Philipp, Gentilini, Maria Virginia, Swallow, Maxine, Bartel, Judith, Lycke, Nils Yngve, Barkan, Daniel, Martina, Mariana, Lujan, Hugo D., Kalay, Hakan, van Kooyk, Yvette, Sparwasser, Tim D., Berod, Luciana
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890140/
https://ncbi.nlm.nih.gov/pubmed/29662482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00471
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