Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys

Cytidine deaminases of the AID/APOBEC family catalyze C-to-U nucleotide transitions in mRNA or DNA. Members of the APOBEC3 branch are involved in antiviral defense, whereas AID contributes to diversification of antibody repertoires in jawed vertebrates via somatic hypermutation, gene conversion, and...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Holland, Stephen J., Berghuis, Lesley M., King, Justin J., Iyer, Lakshminarayan M., Sikora, Katarzyna, Fifield, Heather, Peter, Sarah, Quinlan, Emma M., Sugahara, Fumiaki, Shingate, Prashant, Trancoso, Inês, Iwanami, Norimasa, Temereva, Elena, Strohmeier, Christine, Kuratani, Shigeru, Venkatesh, Byrappa, Evanno, Guillaume, Aravind, L., Schorpp, Michael, Larijani, Mani, Boehm, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889659/
https://ncbi.nlm.nih.gov/pubmed/29555777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720871115
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