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Biochemical Regulatory Features of Activation-Induced Cytidine Deaminase Remain Conserved from Lampreys to Humans

Activation-induced cytidine deaminase (AID) is a genome-mutating enzyme that initiates class switch recombination and somatic hypermutation of antibodies in jawed vertebrates. We previously described the biochemical properties of human AID and found that it is an unusual enzyme in that it exhibits b...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Main Authors: Quinlan, Emma M., King, Justin J., Amemiya, Chris T., Hsu, Ellen, Larijani, Mani
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5615186/
https://ncbi.nlm.nih.gov/pubmed/28716949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00077-17
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