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Protonation state of inhibitors determines interaction sites within voltage-gated sodium channels
Voltage-gated sodium channels are essential for carrying electrical signals throughout the body, and mutations in these proteins are responsible for a variety of disorders, including epilepsy and pain syndromes. As such, they are the target of a number of drugs used for reducing pain or combatting a...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5889629/ https://ncbi.nlm.nih.gov/pubmed/29467289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714131115 |
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