RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression

RAP1 is part of shelterin, the protective complex at telomeres. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expression. To investigate the nontelomeric roles of RAP1 in vivo, we generated a RAP1 whole-body knockout mouse. These mice show early onset of obesity, which...

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Vydáno v:Cell Rep
Hlavní autoři: Martínez, Paula, Gómez-López, Gonzalo, García, Fernando, Mercken, Evi, Mitchell, Sarah, Flores, Juana M., de Cabo, Rafael, Blasco, Maria A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889507/
https://ncbi.nlm.nih.gov/pubmed/23791526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.05.030
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