Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4(+) T cells expressing converged T-cell receptor genes in vitro

DEP domain containing 1 (DEPDC1) and M-phase phosphoprotein 1 (MPHOSPH1) are human cancer testis antigens that are frequently overexpressed in urinary bladder cancer. In a phase I/II clinical trial, a DEPDC1- and MPHOSPH1-derived short peptide vaccine demonstrated promising efficacy in preventing bl...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Tsuruta, Miki, Ueda, Shohei, Yew, Poh Yin, Fukuda, Isao, Yoshimura, Sachiko, Kishi, Hiroyuki, Hamana, Hiroshi, Hirayama, Masatoshi, Yatsuda, Junji, Irie, Atsushi, Senju, Satoru, Yuba, Eiji, Kamba, Tomomi, Eto, Masatoshi, Nakayama, Hideki, Nishimura, Yasuharu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889196/
https://ncbi.nlm.nih.gov/pubmed/29632734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1415687
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