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Suppressed ubiquitination of Nrf2 by p47(phox) contributes to Nrf2 activation

Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti-oxidant enzymes that nullifies ROS, ROS activating Nrf2 is a critical negative regulator...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Kim, Kyun Ha, Sadikot, Ruxana T., Lee, Ji Yeon, Jeong, Han-Sol, Oh, Yu-Kyoung, Blackwell, Timothy S., Joo, Myungsoo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889093/
https://ncbi.nlm.nih.gov/pubmed/28939422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.09.011
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