Suppressed ubiquitination of Nrf2 by p47(phox) contributes to Nrf2 activation

Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti-oxidant enzymes that nullifies ROS, ROS activating Nrf2 is a critical negative regulator...

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Bibliografiska uppgifter
I publikationen:Free Radic Biol Med
Huvudupphovsmän: Kim, Kyun Ha, Sadikot, Ruxana T., Lee, Ji Yeon, Jeong, Han-Sol, Oh, Yu-Kyoung, Blackwell, Timothy S., Joo, Myungsoo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889093/
https://ncbi.nlm.nih.gov/pubmed/28939422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.09.011
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