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C1206, a novel curcumin derivative, potently inhibits Hsp90 and human chronic myeloid leukemia cells in vitro

4-(4-Pyridinyl methylene) curcumin (C1206) is a new derivative of curcumin that is more active than curcumin in inhibition of heat shock protein 90 (Hsp90) and antitumor action. In this study we investigated the relationship between C1206-induced inhibition of Hsp90 and its anti-leukemic effects. Th...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Fan, Ying-juan, Zhou, Yi-xiang, Zhang, Lian-ru, Lin, Qiao-fa, Gao, Ping-zhang, Cai, Fang, Zhu, Li-ping, Liu, Bi, Xu, Jian-hua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888686/
https://ncbi.nlm.nih.gov/pubmed/29219946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.160
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