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S43. A PROOF-OF-MECHANISM STUDY OF THE PDE10 INHIBITOR RG7203 IN PATIENTS WITH PROBING REWARD FUNCTIONS WITH IMAGING AND BEHAVIORAL APPROACHES

BACKGROUND: The enzyme phosphodiesterase 10A (PDE10A) is highly expressed in the striatum where it modulates both dopamine D2 and D1 dependent signaling. Its inhibition leads to a suppression of D2 mediated signaling –similar to effects of D2 antagonists - and an enhancement of D1 dependent signalin...

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Bibliografske podrobnosti
izdano v:Schizophr Bull
Main Authors: Umbricht, Daniel, Dukart, Jürgen, Abt, Markus, Tamburri, Paul, Chatham, Chris, Frank, Michael, Collins, Anne, Walling, David, Mofsen, Rick, Gruener, Daniel, Gertsik, Lev, Sevigny, Jeffrey
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888501/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sby018.830
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