A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart

Chromatin remodelling precedes transcriptional and structural changes in heart failure. A body of work suggests roles for the developmental Wnt signalling pathway in cardiac remodelling. Hitherto, there is no evidence supporting a direct role of Wnt nuclear components in regulating chromatin landsca...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Iyer, Lavanya M, Nagarajan, Sankari, Woelfer, Monique, Schoger, Eric, Khadjeh, Sara, Zafiriou, Maria Patapia, Kari, Vijayalakshmi, Herting, Jonas, Pang, Sze Ting, Weber, Tobias, Rathjens, Franziska S, Fischer, Thomas H, Toischer, Karl, Hasenfuss, Gerd, Noack, Claudia, Johnsen, Steven A, Zelarayán, Laura C
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2018
Pynciau:
Gene regulation, Chromatin and Epigenetics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887416/
https://ncbi.nlm.nih.gov/pubmed/29394407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky049
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