A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart

Chromatin remodelling precedes transcriptional and structural changes in heart failure. A body of work suggests roles for the developmental Wnt signalling pathway in cardiac remodelling. Hitherto, there is no evidence supporting a direct role of Wnt nuclear components in regulating chromatin landsca...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Iyer, Lavanya M, Nagarajan, Sankari, Woelfer, Monique, Schoger, Eric, Khadjeh, Sara, Zafiriou, Maria Patapia, Kari, Vijayalakshmi, Herting, Jonas, Pang, Sze Ting, Weber, Tobias, Rathjens, Franziska S, Fischer, Thomas H, Toischer, Karl, Hasenfuss, Gerd, Noack, Claudia, Johnsen, Steven A, Zelarayán, Laura C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887416/
https://ncbi.nlm.nih.gov/pubmed/29394407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky049
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