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CCL17 blockade as a therapy for osteoarthritis pain and disease

BACKGROUND: Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of inflammatory diseases and in osteoarthritis (OA). We identified previously a new GM-CSF→Jmjd3→interferon regulatory factor 4 (IRF4)→chemokine (c-c motif) ligand 17 (CCL17) pat...

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Publicado en:Arthritis Res Ther
Autores principales: Lee, Ming-Chin, Saleh, Reem, Achuthan, Adrian, Fleetwood, Andrew J., Förster, Irmgard, Hamilton, John A., Cook, Andrew D.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887260/
https://ncbi.nlm.nih.gov/pubmed/29622035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1560-9
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