The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53

Hypermethylated-in-Cancer 1 (Hic1) is a tumor suppressor gene frequently inactivated by epigenetic silencing and loss-of-heterozygosity in a broad range of cancers. Loss of HIC1, a sequence-specific zinc finger transcriptional repressor, results in deregulation of genes that promote a malignant phen...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Szczepny, Anette, Carey, Kirstyn, McKenzie, Lisa, Jayasekara, W. Samantha N., Rossello, Fernando, Gonzalez-Rajal, Alvaro, McCaw, Andrew S., Popovski, Dean, Wang, Die, Sadler, Anthony J., Mahar, Annabelle, Russell, Prudence A., Wright, Gavin, McCloy, Rachael A., Garama, Daniel J., Gough, Daniel J., Baylin, Stephen B., Burgess, Andrew, Cain, Jason E., Watkins, D. Neil
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Brief Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886987/
https://ncbi.nlm.nih.gov/pubmed/29367758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0022-1
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki