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Ultrafiltered recombinant AAV8 vector can be safely administered in vivo and efficiently transduces liver

Viral vectors are extensively purified for use in biomedical research, in order to separate biologically active virus particles and to eliminate production related impurities that are assumed to be detrimental to the host. For recombinant adeno-associated virus (rAAV) vectors this is typically accom...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Kleven, Mark D., Gomes, Michelle M., Wortham, Aaron M., Enns, Caroline A., Kahl, Christoph A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886455/
https://ncbi.nlm.nih.gov/pubmed/29621273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194728
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