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Phenotype and biochemical heterogeneity in late onset Fabry disease defined by N215S mutation

BACKGROUND: Fabry disease (FD) results from X-linked inheritance of a mutation in the GLA gene, encoding for alpha galactosidase A, and is characterized by heterogeneous clinical manifestations. Two phenotypes have been described “Classic” and “late onset” which cannot be predicted exclusively by ge...

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Publicado en:PLoS One
Main Authors: Lavalle, L., Thomas, A. S., Beaton, B., Ebrahim, H., Reed, M., Ramaswami, U., Elliott, P., Mehta, A. B., Hughes, D. A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886405/
https://ncbi.nlm.nih.gov/pubmed/29621274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193550
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