Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice

The Dlk1-Dio3 imprinted domain functions in embryonic development but the roles of noncoding RNAs expressed from this domain remain unclear. We addressed this question by generating transgenic (TG) mice harbouring a BAC carrying IG-DMR (intergenic-differentially methylated region), Gtl2-DMR, Gtl2, R...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Kumamoto, Soichiro, Takahashi, Nozomi, Nomura, Kayo, Fujiwara, Makoto, Kijioka, Megumi, Uno, Yoshinobu, Matsuda, Yoichi, Sotomaru, Yusuke, Kono, Tomohiro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886287/
https://ncbi.nlm.nih.gov/pubmed/28934383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx223
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