Myostatin inhibition using mRK35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1(D286G) nemaline myopathy mice

Nemaline myopathy (NM) is a heterogeneous congenital skeletal muscle disease with cytoplasmic rod-like structures (nemaline bodies) in muscle tissue. While weakness in NM is related to contractile abnormalities, myofiber smallness is an additional abnormality in NM that may be treatable. We evaluate...

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Udgivet i:Hum Mol Genet
Main Authors: Tinklenberg, Jennifer A, Siebers, Emily M, Beatka, Margaret J, Meng, Hui, Yang, Lin, Zhang, Zizhao, Ross, Jacob A, Ochala, Julien, Morris, Carl, Owens, Jane M, Laing, Nigel G, Nowak, Kristen J, Lawlor, Michael W
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886278/
https://ncbi.nlm.nih.gov/pubmed/29293963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx431
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