Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy

Nemaline myopathies (NMs) are a group of congenital muscle diseases caused by mutations in at least 10 genes and associated with a range of clinical symptoms. NM is defined on muscle biopsy by the presence of cytoplasmic rod-like structures (nemaline rods) composed of cytoskeletal material. Myofiber...

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Udgivet i:Am J Pathol
Main Authors: Tinklenberg, Jennifer, Meng, Hui, Yang, Lin, Liu, Fujun, Hoffmann, Raymond G., Dasgupta, Mahua, Allen, Kenneth P., Beggs, Alan H., Hardeman, Edna C., Pearsall, R. Scott, Fitts, Robert H., Lawlor, Michael W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2016
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901141/
https://ncbi.nlm.nih.gov/pubmed/27102768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.02.008
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