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A zebrafish model of X-linked adrenoleukodystrophy recapitulates key disease features and demonstrates a developmental requirement for abcd1 in oligodendrocyte patterning and myelination

X-linked adrenoleukodystrophy (ALD) is a devastating inherited neurodegenerative disease caused by defects in the ABCD1 gene and affecting peripheral and central nervous system myelin. ABCD1 encodes a peroxisomal transmembrane protein required for very long chain fatty acid (VLCFA) metabolism. We sh...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Strachan, Lauren R., Stevenson, Tamara J., Freshner, Briana, Keefe, Matthew D., Miranda Bowles, D., Bonkowsky, Joshua L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886093/
https://ncbi.nlm.nih.gov/pubmed/28911205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx249
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