APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

The ε4 allele of the APOE gene encoding apolipoprotein E (apoE) is a strong genetic risk factor for aging-related cognitive decline as well as late-onset Alzheimer’s disease (AD) compared to the common ε3 allele. In the central nervous system, apoE is produced primarily by astrocytes and functions i...

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Pubblicato in:Hum Mol Genet
Autori principali: Zhao, Jing, Davis, Mary D., Martens, Yuka A., Shinohara, Mitsuru, Graff-Radford, Neill R., Younkin, Steven G., Wszolek, Zbigniew K., Kanekiyo, Takahisa, Bu, Guojun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886091/
https://ncbi.nlm.nih.gov/pubmed/28444230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx155
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